WebDec 12, 2024 · Downregulation of tumor suppressor (TS) microRNAs (miRNAs) commonly occurs in human cancer, including multiple myeloma (MM). We previously demonstrated … WebDec 12, 2024 · Downregulation of tumor suppressor (TS) microRNAs (miRNAs) commonly occurs in human cancer, including multiple myeloma (MM). We previously demonstrated that miR-29b is a relevant TS miRNA, whose expression in MM cells is inhibited by HDAC4-dependent deacetylation. Here, we provide novel insights into epigenetic mechanisms …
PHF19 Promotes Drug Resistance via Increased EZH2 …
WebREVIEW Open Access EZH2 as a therapeutic target for multiple myeloma and other haematological malignancies Rosemarie Tremblay-LeMay1, Nasrin Rastgoo2, Maryam Pourabdollah1 and Hong Chang1,2,3* Abstract Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is of great interest in human cancer. WebFeb 13, 2024 · Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple … blank california notary acknowledgement form
Cancers Free Full-Text HDAC2- and EZH2-Mediated Histone ...
WebEZH2 phosphorylation suppresses H3K27me3, resulting in upregulation of downstream targets (BCL-xL, MCL-1 and HIF-1α) that promote cell growth. Importantly, PHF19 overexpression is not caused by DNA amplification of chromosome 9q, but by the direct downregulation of miR-15a. Conclusions WebMar 9, 2024 · When PARPi is used, alkylating DNA damage-induced EZH2 downregulation would be disturbed, and EZH2-mediated gene silencing and cancer stem cell property are enhanced, leading to decreased sensitivity of PARPi . However, in acute myeloid leukemia (AML), loss of the histone methyltransferase EZH2 and subsequent reduction of histone … WebSep 3, 2024 · EZH2 is a common epigenetic enzyme that has been shown to be deregulated in MM. Initial global gene expression profiling in MM, MGUS and normal BM plasma cells has revealed EZH2 overexpression in an aggressive MM subgroup with a gene expression profile resembling that of human MM cell lines (HMCLs); a representative of the most … blank calendar with times