Web1 apr. 2024 · Chronic kidney disease (CKD) is characterized by progressive scarring that results in loss of normal tissue in the kidney and eventually end-stage kidney disease. 1 … WebIntroduction. The relation between the heart and kidney was first described by Robert Bright in 1836, but until 2005, the term cardiorenal syndrome (CRS) was not properly defined as “disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other” (Table 1).There are risk factors that co …
Type-I Interferon Receptor Deficiency Reduces Lupus-like …
Web5 mei 2024 · The authors demonstrated that mice with macrophage-specific deletion of the gene encoding IFN regulatory factor 4 (Irf4), a mediator of myeloid polarization, exhibited … Web13 nov. 2015 · In order to induce kidney injury, FVB/NJ mice received folic acid (200 mg/kg) in NaHCO 3 (0.15 M) vehicle i.p. according to the protocol established by Klingler et al. adapted by our laboratory. At the determined time, animals were killed by anesthetic overdose of xilazine /ketamine (Agribands, Brazil) to obtain kidney and blood samples. plymouth mich weather radar
Renal Inflammation and Fibrosis: A Double-edged Sword
Web9 apr. 2024 · Abolished VHL gene expression in mice induces hyperplastic clear cell lesions with severe inflammation and fibrosis . This inflammatory response was associated with increased inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) kinase activity required for the polarization and recruitment of inflammatory macrophages [ 53 ]. Web12 jan. 2024 · However, injured proximal tubule epithelial cells are still considered important drivers of kidney injury and fibrosis, as e.g., also recently demonstrated by scRNA-seq studies in mouse models of acute kidney injury (21, 22). snRNA-seq in a fibrosis mouse model of chronic aristolochic acid administration identified novel classes of proximal … Web29 okt. 2024 · Kidney fibrosis is associated with the progression of acute kidney injury to chronic kidney disease. MG53, a cell membrane repair protein, has been shown to protect against injury to kidney epithelial cells and acute kidney injury. Here, we evaluated the role of MG53 in modulation of kidney fibrosis in aging mice and in mice with unilateral … prinox chambery