Kinetochore protein ndc80
WebComponent of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore …
Kinetochore protein ndc80
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WebThus, the overexpression of Ndc80/Hec1, an outer kinetochore protein involved in spindle assembly checkpoint (SAC) recruitment, has been shown to induce tumor formation in … WebDisclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome …
WebMany central kinetochore proteins, including components of the Ndc80, Mis12/Mtw1, and Ctf19 complexes, remain to be identified in mammals. Identification of these components … WebThe spindle checkpoint : Bubs, Mads, and chromosome-microtubule attachment in budding yeast . Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2005. === Includes bibliographical references. === (cont.) DNA damage response, we hypothesize that the perinuclear pool of Mad proteins may be required for spindle …
WebThe NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules … WebLoad the protein mix into the well of an SDS-PAGE gel and perform electrophoresis. Higher molecular weight SUMOylated proteins move slower than their non-SUMOylated variants, generating two distinct bands. Transfer the gel onto a blotting membrane present on a wet filter paper in an electroblotting apparatus.
WebDescription: Homo sapiens NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) (NUF2), transcript variant 2, mRNA. RefSeq Summary (NM_031423): This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere …
Web16 feb. 2011 · Hec1/Ndc80 also contains a calponin homology domain ... or Kntc2 (kinetochore-associated protein 2), a kinetochore protein directly involved in kinetochore microtubule interactions, ... helicopter crash in arunachalWebKinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment... lake elementary school uniontown ohioWeb21 mrt. 2024 · Ndc80's interaction with either growing or shrinking microtubule ends can be tuned by the phosphorylation state of its tail. The Ndc80 internal loop is essential for end … lake elizabeth estates columbia schttp://www.stemcell8.cn/forum.php?mod=viewthread&tid=5684 helicopter crash in balochistanhttp://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=1604222127_uzhuYwVI7yBfSCo4gYPQW8c0c2M8&db=mm39&hgg_gene=ENSMUST00000024851.10&hgg_chrom=chr17&hgg_start=71803094&hgg_end=71833852 helicopter crash in baton rougeWebKinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene. Contents. 1 Function; 2 Interactions; 3 References; 4 Further reading; … lake elementary school saint amantWeb11 feb. 2011 · The Ndc80 complex lies at the heart of the kinetochore, a large protein machine that accurately segregates chromosomes during cell division. The Ndc80 … helicopter crash in bronson fl