WebmTOR 进化上相对保守,可整合营养、能量及生长因子等多种细胞外信号,参与基因转录、蛋白质翻译、核糖体合成等生物过程,在细胞生长、凋亡、自噬及代谢等过程中发挥了 … Web1 apr. 2013 · Our main finding was that, although repeated bouts of exercise blunted the phosphorylation of the mTOR downstream target p70S6K and rpS6, short-term …
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WebMagnuson B, Ekim B, Fingar DC (2012) Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem. J. 441(1), 1–21. Ruvinsky I, … Web29 dec. 2024 · mTOR 通路是如何调控自噬的. mTOR 是细胞生长和代谢的主要调节分子,可促进合成代谢过程,如核糖体的生物发生 (Ribosome biogenesis) 以及蛋白质、核苷 … pumpkin cheesecake bites recipe
mTOR信号传导通路及运动对其影响的分子机制综述
Web26 mar. 2024 · These alterations to RPS6 gene expression mirrored the phenotypes observed in equivalent TOR-modulated lines, emphasizing the critical roles of TOR and RPS6 in mRNA translational control and their intimate connection with life span determination. These studies emphasized the key role of protein synthesis and its … WebMagnuson B, Ekim B, Fingar DC (2012) Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem. J. 441(1), 1–21. Ruvinsky I, … WebSimilarly, phosphorylation of rpS6, the canonical S6K substrate, was intact in adipose tissue from FLCN adipKO animals (Fig. 4C). Thus, signaling from mTOR to one of its canonical substrates remains intact in the absence of FLCN despite the complete abrogation of mTOR signaling to TFE3. sec ellsworth rd \u0026 pecos rd mesa az 85212