WebFeb 20, 2024 · A total of 5 members of the TSP family (TSP1-5) have been identified so far, and are divided into two subgroups, subgroup A and subgroup B, according to their … WebApr 23, 2024 · TSP-1 is known as an inhibitor of proliferation in endothelial cells 19 and induces apoptosis, 20 and suppresses the cell cycle. 21 TSP-1 is under-expressed in …
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WebAug 1, 2016 · Aberrant methylation was an important reason for the downregulation of THBS‑1 and was involved in the invasion and metastasis of LSCC. Demethylating agents … We first confirmed our observations16,17, showing that genotoxic treatments induce senescence. p21waf1 was upregulated and CIS was confirmed using SA-β-galactosidase, PML bodies, and ɣ-H2AX staining in LS174T colorectal cells and MCF7 breast cells (Fig. 1a, supplementary Figure 1). We recently … See more To determine if secreted factors were involved in senescence escape, we exposed parental LS174T cells to a conditioned medium (CM) obtained from PLC … See more We then determined if cell emergence was explained by a modulation of CD47 and TSP1. Using immunofluorescence staining, we observed that the PLD-dividing … See more We then determined if p21waf1 was necessary to maintain senescence. To this end, the cell cycle inhibitor was downregulated by RNA interference following … See more We confirmed these results in primary WI38 pulmonary fibroblasts. Using clonogenic tests, we did not observe any effect of TSP1 on proliferation (Fig. 8a). To … See more fish was off crossword
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WebMay 12, 2024 · TSP1 may also regulate adipocytes through a cell-autonomous mechanism of TSP1 in adipocytes given that adipocytes also express TSP1 (despite at much lower … WebFeb 1, 2008 · TSP1 was initially isolated from platelets and megakaryocytes and was later detected in many other cell types, including macrophages and adipocytes (13–16).TSP1 … WebThrombospondin-1 (TSP1) is a potent peptide shown in some tumor systems to be linked with angiogenesis. Epigenetic alteration of TSP1 has been reported in various primary … fish washington wdfw